Please use this identifier to cite or link to this item: http://apsciencelibrary.com/handle/123456789/8231
Title: 3D Series Metal Complexes Containing Schiff Base Ligand with 2,2'-Bipyridine: Synthesis, Characterization and Assessment of Antifungal Activity
Authors: Kpomah, B.
Ugbune, U.
E. Idu, T.
Keywords: Methylphenylketone
2, 2’-bipyridine
synthesis
complexes
spectroscopy
pathogenic fungi
antifungal assessment
Issue Date: 8-Dec-2021
Publisher: CSIJ
Abstract: The rapid increase in the number of multidrug-resistant of most pathogenic organisms is fast becoming a global concern, thus, the discovery of novel active pharmacological compounds against new targets is a matter of urgency. The incorporation of metal ions into organic ligands has introduced metal-organic drugs framework with synergistic effects for novel applications in the biological system. In this research work, metal(II) chloride complexes of copper, nickel and zinc containing methylphenylketone thiosemicarbazone (MPK-TSC) with 2,2’-bipyridine (bipy) were synthesized; they were further characterized by satisfactory microelemental analysis, Fourier Transform InfraRed (FTIR) spectra as well as electronic spectra study. The complexes are proposed to have the formulae [L1ML2(Cl2)] where M=metal ion, L1=methylphenylketone thiosemicarbazone L2=2,2’-bipyridine. The complexes are of 1:2 (metal:ligand) stoichiometry and non-electrolytes in solution, the bidentate nature of the two ligands was evident from the FTIR spectra. The compounds were screened for their antifungal activity against four pathogenic fungi: Aspergillus niger, Penicillium Species, Rizopus and Candida albicans using disc diffusion method. The activities of the complexes have been found to be greater than those of the metal salts and the uncoordinated ligands.
URI: http://libraryaplos.com/xmlui/handle/123456789/8231
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